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2024-05-16


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Program SnapshotThe goal of the Common Fund's 4D Nucleome (4DN) program is to study the three-dimensional organization of the nucleus in space and time (the 4th dimension). The nucleus of a cell contains DNA, the genetic "blueprint" that encodes all of the genes a living organism uses to produce proteins needed to carry out life-sustaining cellular functions.

The 4D Nucleome (4DN) Network aims to elucidate the complex structure and organization of chromosomes in the nucleus and the impact of their disruption in disease biology. We present the 4DN Data ...

4D Nucleome Tutorial Series #2. "Multimodal Visualization for 4DN data using Nucleome Browser and OME" October 28, 2022 8AM - 9AM PST; Virtual on Zoom.... Read more. October 21, 2022. 4DN News and Announcements. 1. 2. Next. The 4D Nucleome (4DN) Program aims to explore the 3D organization of the DNA in the nucleus & how it changes over ...

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These three main components are illustrated in Fig. 1. Figure 1. The 4D Nucleome project. The project encompasses three components: First, experimental mapping approaches are employed to measure a range of aspects of the spatial organization of the genome including chromatin loops, domains, nuclear bodies etc. Second, computational and modeling ...

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